Our manuscript, “TRIM34 acts with TRIM5 to restrict HIV-1 and SIV capsids”, is now online at bioRxiv. This manuscript is the result of a great tri-lab collaboration. 

The story springs from a CRISPR loss-of-function screen that was brilliantly designed and expertly conducted by Molly Ohainle in the lab of lab of Michael Emerman at the Hutch in Seattle. Kyusik Kim from my lab at UMass Medical School confirmed the role of these TRIM proteins in primary human blood cells. Our wonderful collaborator Sevnur Komurlu in Ed Campbell’s lab at Loyola Univ in Chicago provides the groovy images. 

Figure from the manuscript shows the brilliant Ohainle CRISPR screen