please scroll down the page to see the key to the above images
Welcome to the Luban Lab
….where we study viral replication, pathogenesis, and immunity
…and attempt to learn about ourselves in the process
You may navigate using the menu, where you will find links to our NewsBlog, descriptions of our research, current lab members, lab alumni, collaborators, positions, funding, contact information, links, and a page explaining how you may support our research.
Key to above images:
1. Logo of the University of Massachusetts Medical School, the public medical school of the Commonwealth of Massachusetts where the Luban Lab is located.
2. HIV-1 virion cut-away by autopack.org, courtesy of Graham Johnson & colleagues.
3. Micrograph of dendritic cells derived from CD34+ human hematopoietic stem cells, 2 hrs after stimulation with LPS. Note spiky dendrites! Courtesy Sean McCauley.
4. The South American owl monkey (Aotus trivirgatus):
– is monogamous, nocturnal, and weighs ~ 1 kg
– engages in social annointing/group intoxication with crushed millepedes
– encodes TRIM5Cyp, to our knowledge the most potent anti-HIV-1 restriction factor
5. FACS plot of human monocyte derived dendritic cells, 48 hrs after challenge with HIV-1-GFP, showing infected cells (GFP+, X-axis) and matured cells (CD86+, Y-axis).
6. RNA-Seq data from human blood monocyte derived DCs, in a time-course after stimulation with multiple factors.
7. An emu (Dromaius novaehollandiae) resided in the UCSF office of Harold Varmus for studies leading to the discovery of oncogenes (verbal communication, Paul Bates)
“Dominique (Stahelin) then used the src probe in molecular hybridization experiments to look for evidence of src-related DNA, revealed by base pairing, in normal DNA from a variety of birds. The results were unambiguous and stunning: DNA closely related to the viral src gene was present in normal DNA—first from chickens and then from other birds, such as duck, turkey, quail, and even, most memorably, an emu we obtained from the Sacramento Zoo.” – Harold Varmus